About

Simpson Biotech Co., Ltd. (SBC), a private Co. founded in 1998, located in Taiwan is focusing on: (I). Medicinal fungus fermentation & enzymatically hydrolyzed bioactive natural ingredients used for dietary supplements, cosmetics & drug discovery. (II). OEM/ODM services for Recombinant Proteins (i.e. Industrial Enzymes), using a patented starch-binding protein as the affinity tag. New product launched in 2023: 1. Antrodia cinnamomea extract as natural ingredient for cosmetics formulation, 2. Potent anti-yeast & anti-bacteria soluble chitosan for food/drug & agriculture applications; 2. World's first high purity (chitobiose+chitotriose > 90%) oligo chitosan for weight, diabetes and triglyceride control; 3. Hydrolyzed Fucoidan for immune & glucose control. SBC has won numerous awards with 54 patents issued. ----->----- 【Natural Compound as Oral Drug development for NAFLD/NASH】  Reduce liver triglyceride and cholesterol in NAFLD  Reduce serum triglyceride and cholesterol in NAFLD  Reduce liver fat deposition in NAFLD  Reduce ALT and AST in NAFLD  Anti-inflammation and oxidative stress  Anti-fibrosis  US, CN, TW patents granted 【Recombinant Protein Expression/Purification Platform (HERPEPSTM) and Products】  Patent Recombinant Protein Platform & CDMO Service – Cost-effective recombinant protein expression & purification system; From gene to protein  Starch Binding Protein (SBP) as an affinity tag  One-step purification of recombinant protein by starch  Protein immobilization on starch enhanced the thermostability & shelf life  Easy to scale up: From 100L lab-scale concept proof to 8000L mass production  Ideal for industrial, food, feed enzymes  Self-owned Tool Box for Protein Expression in Pichia pastoris  Methanol-induced or Methanol-free expression  Antibiotics-free expression host  Genetic manipulation of expression strain with high yield  Cost can be 12%) of Simpson Biotech's currently marketed dietary supplement actually illustrates both the safety and the effectiveness of the mycelia and the compound of Hepasim® through human clinical studies. One clinical study for Rheumatoid Arthritis (RA) has been completed. Initial results from the clinical study plus the previous metabolic/pharmacokinetic animal studies on these compounds already illustrate that Hepasim® is a promising NCE drug candidate. 【Fermented natural products for dietary supplement】  Alcoholic Hangover Release : Antrodia cinnamomea mycelia  Neuroprotective & Memory Enhancement : Ginsenoside compound K  Immune Regulation : Cordyceps sinensis mycelia, Hydrolyzed Fucoidan  Male Hormone (Testosterone) Stimulant : Cordyceps sinensis mycelia  Heart Protection : Agaricus blazei murill  Increase Stamina : low molecular weight functional peptides from casein, whey, soy, collagen, silk  OEM/ODM Fermentation : Cordyceps sinensis, Phellinus linteus, Ganoderma lucidum, Agaricus blazei murill and other mycelia and their extracts  Fermented Vegetables & Grains Concentrate as prebiotics  Cosmetics for skin whitening & anti-scar : Antrodia cinnamomea extract 【Immune booster for IFN-γ stimulation as anti-viral and antibiotic alternative feed additive】 LZ-8 is a fungal immunomodulatory protein originally isolated from the popular oriental medicinal fungus. Oral administration of rLZ-8 stimulates IFN-γ secretion. It is not only a good dietary supplement for humans but also an antibiotic alternative for animal additives for the prevention of virus or coccidia infection in field studies. Possible pharmaceutical applications per oral include immune-regulatory diseases.  IFN-γ Stimulant  Anti-viral  Antibiotic alternative  Anti-coccidia  Increase feed efficiency  US, TW, CN patent granted (US9950028, I589586, CN106232133A) About Simpson Biotech Co., Ltd. Simpson Biotech Co., Ltd. (SBC), a private Co. founded in 1998, located in Taiwan is focusing on: (I). Medicinal fungus fermentation & enzymatically hydrolyzed bioactive natural ingredients used for dietary supplements, cosmetics & drug discovery. (II). OEM/ODM services for Recombinant Proteins (i.e. Industrial Enzymes), using a patented starch-binding protein as the affinity tag and in-house non-methanol, antibiotics-free expression strain. Highlight in 2024: 1. Recombinant protein OEM/ODM with proprietary yeast platform, 2. Antrodia cinnamomea extract as natural ingredient for cosmetics formulation. 3. Antrodin as potent oral drug for NAFLD/NASH; 4. Natural anti-yeast & anti-bacteria soluble chitosan for food/drug & agriculture applications; SBC has won numerous awards with 54 patents issued. ----->----- 【Recombinant Protein OEM/ODM with Proprietary Yeast Platform】 - One-step purification of recombinant protein by starch - Protein immobilization on starch enhanced the thermostability & shelf life - Easy to scale up: From 100L lab-scale concept proof to 8000L mass production - Ideal for industrial, food, feed enzymes - Turn-key licensed(non-exclusive) to global feed company already > - In-house Non-Methanol promoter compared to AOX1 - Antibiotics-free expression strain: Eco-friendly - Genetic manipulation of expression strain with high yield - Cost can be 12%) of Simpson Biotech's currently marketed dietary supplement actually illustrates both the safety and the effectiveness of the mycelia and the compound of Hepasim® through human clinical study for Rheumatoid Arthritis (RA). - Initial results from the clinical study plus the previous metabolic/pharmacokinetic animal studies on these compounds already illustrate that Hepasim® is a promising NCE drug candidate. 【Fermented natural products for dietary supplement】 - Alcoholic Hangover Release : Antrodia cinnamomea mycelia - Neuroprotective & Memory Enhancement : Ginsenoside compound K - Immune Regulation : Cordyceps sinensis mycelia, Hydrolyzed Fucoidan - Male Hormone (Testosterone) Stimulant : Cordyceps sinensis mycelia - Heart Protection : Agaricus blazei murill - Increase Stamina : low molecular weight functional peptides from casein, whey, soy, collagen, silk - OEM/ODM Fermentation : Cordyceps sinensis, Phellinus linteus, Ganoderma lucidum, Agaricus blazei murill and other mycelia and their extracts - Fermented Vegetables & Grains Concentrate as prebiotics - Cosmetics for skin whitening & anti-scar : Antrodia cinnamomea extract 【Immune booster for IFN-γ stimulation as anti-viral and antibiotic alternative feed additive】 LZ-8 is a fungal immunomodulatory protein originally isolated from the popular oriental medicinal fungus. Oral administration of rLZ-8 stimulates IFN-γ secretion. It is not only a good dietary supplement for humans but also an antibiotic alternative for animal additives for the prevention of virus or coccidia infection in field studies. Possible pharmaceutical applications per oral include immune-regulatory diseases. - IFN-γ Stimulant - Anti-viral - Antibiotic alternative - Anti-coccidia - Increase feed efficiency - US, TW, CN patent granted (US9950028, I589586, CN106232133A) About Simpson Biotech Co., Ltd. Simpson Biotech Co., Ltd. (SBC), a private Co. founded in 1998, located in Taiwan is focusing on: (I). Medicinal fungus fermentation & enzymatically hydrolyzed bioactive natural ingredients used for dietary supplements, cosmetics & drug discovery. (II). OEM/ODM services for Recombinant Proteins (i.e. Industrial Enzymes), using a patented starch-binding protein as the affinity tag and in-house non-methanol, antibiotics-free expression strain. Highlight in 2024: 1. Recombinant protein OEM/ODM with proprietary yeast platform, 2. Antrodia cinnamomea extract as natural ingredient for cosmetics formulation. 3. Antrodin as potent oral drug for NAFLD/NASH; 4. Natural anti-yeast & anti-bacteria soluble chitosan for food/drug & agriculture applications; SBC has won numerous awards with 54 patents issued. ----->----- 【Recombinant Protein OEM/ODM with Proprietary Yeast Platform】 - One-step purification of recombinant protein by starch - Protein immobilization on starch enhanced the thermostability & shelf life - Easy to scale up: From 100L lab-scale concept proof to 8000L mass production - Ideal for industrial, food, feed enzymes - Turn-key licensed(non-exclusive) to global feed company already > - In-house Non-Methanol promoter compared to AOX1 - Antibiotics-free expression strain: Eco-friendly - Genetic manipulation of expression strain with high yield - Cost can be 12%) of Simpson Biotech's currently marketed dietary supplement actually illustrates both the safety and the effectiveness of the mycelia and the compound of Hepasim® through human clinical study for Rheumatoid Arthritis (RA). - Initial results from the clinical study plus the previous metabolic/pharmacokinetic animal studies on these compounds already illustrate that Hepasim® is a promising NCE drug candidate. 【Fermented natural products for dietary supplement】 - Alcoholic Hangover Release : Antrodia cinnamomea mycelia - Neuroprotective & Memory Enhancement : Ginsenoside compound K - Immune Regulation : Cordyceps sinensis mycelia, Hydrolyzed Fucoidan - Male Hormone (Testosterone) Stimulant : Cordyceps sinensis mycelia - Heart Protection : Agaricus blazei murill - Increase Stamina : low molecular weight functional peptides from casein, whey, soy, collagen, silk - OEM/ODM Fermentation : Cordyceps sinensis, Phellinus linteus, Ganoderma lucidum, Agaricus blazei murill and other mycelia and their extracts - Fermented Vegetables & Grains Concentrate as prebiotics - Cosmetics for skin whitening & anti-scar : Antrodia cinnamomea extract 【Immune booster for IFN-γ stimulation as anti-viral and antibiotic alternative feed additive】 LZ-8 is a fungal immunomodulatory protein originally isolated from the popular oriental medicinal fungus. Oral administration of rLZ-8 stimulates IFN-γ secretion. It is not only a good dietary supplement for humans but also an antibiotic alternative for animal additives for the prevention of virus or coccidia infection in field studies. Possible pharmaceutical applications per oral include immune-regulatory diseases. - IFN-γ Stimulant - Anti-viral - Antibiotic alternative - Anti-coccidia - Increase feed efficiency - US, TW, CN patent granted (US9950028, I589586, CN106232133A) Simpson Biotech Co., Ltd. specializes in bio-fermentation development and commercialization: 1. Medicinal fungi for dietary supplements and early-stage drug discovery, specifically Hepasim®. 2. SimpsonPure health supplements portfolios. 3. Patented platform developing for recombinant protein expression and purification. We are seeking partnerships for the development of new recombinant proteins.