About

About Progeria Research Foundation The Progeria Research Foundation (PRF) was established in 1999 by the parents of Sam Berns, a child diagnosed with Progeria at the age of 2. Progeria is an ultra-rare fatal genetic condition that results in accelerated aging in children. PRF is the only non-profit organization solely dedicated to finding treatments and the cure for Progeria. Due to the ultra-rare nature of the disease, no for-profit institution will work to find a cure for this fatal disease so PRF has taken on the role of Drug Developer. In 2020 the first treatment for Progeria (lonafarnib) was FDA approved, followed by approvals in 2022 in the EU and 2024 in Japan. PRF now has a pipeline of investigative therapies that includes small molecules as well as RNA and Gene therapies.