About

About ORF Biologics, Inc. ORF Biologics is a mission-driven, high-impact, Iowa-based biotechnology company advancing the rapid development of next-generation proteins, peptides, antibodies, therapeutics, diagnostics, and vaccines for human and animal health, as well as national defense. Founded by scientists with deep industrial and academic experience, we combine synthetic biology with advanced biomanufacturing to engineer proteins that are difficult to produce yet critically needed. Our capabilities span multiple expression systems paired with a complete bioproduction infrastructure: upstream design, downstream manufacturing and purification, and in-house quality control. This allows us to move quickly from gene to purified protein, supporting programs in infectious disease, neurodegeneration, regenerative medicine, oncology, agriculture and the veterinary industry, biodefense and more. At ORF Biologics, we are redefining what regional biotech can achieve. We specialize in the design and production of custom biologics—tailored proteins and antibodies that meet specific functional, structural, or delivery requirements. Whether it’s producing recombinant viral antigens for diagnostics, growth factors for tissue culture-based modeling and cell therapy, or novel fusion proteins for targeted delivery and therapeutic efficacy using animal models, ORF Biologics matches the right host system and production method to each molecule. Our synthetic biology workflows enable rapid prototyping, codon optimization, secretion tagging, and fusion design, while our modular infrastructure allows for efficient purification and scalability. From difficult-to-express glycoproteins to secreted immune modulators and neuroprotective candidates, we provide full-spectrum support—from DNA construct to quality-controlled protein—in a fraction of the typical development time at a lower cost. We work closely with industry, government, and academic partners to translate urgent needs into quality custom biologics, delivered with speed, precision, and domestic manufacturing independence.