SIEVEWELL is an innovative single‑cell arraying platform designed to precisely isolate, position, and analyze individual cells in a high‑throughput and user‑friendly manner. Built around a robust nanowell architecture, SIEVEWELL enables efficient capture of single cells with minimal doublets, making it ideal for applications that require accurate cell‑to‑cell resolution. The platform is optimized for a wide range of cell types, including suspension and primary cells, and supports controlled co‑culture experiments such as target–effector pairing studies. Its gravity‑based loading process eliminates the need for complex microfluidic control systems, allowing researchers to achieve reproducible single‑cell occupancy using standard laboratory equipment. SIEVEWELL is fully compatible with automated imaging systems and downstream assays, including fluorescence‑based viability, functional readouts, and time‑lapse observations. The transparent substrate and standardized layout enable seamless integration with high‑content imaging platforms, facilitating quantitative single‑cell analysis at scale. Designed with simplicity, reproducibility, and flexibility in mind, SIEVEWELL accelerates single‑cell research by reducing experimental complexity while maintaining high data quality. It is an ideal solution for immunology, oncology, cell therapy development, and functional single‑cell assays where precise spatial control and reliable single‑cell data are essential. | SIEVEWELL™ is high density single cell arraying device. This device has a self-standing filter membrane with 370,000(type Hex20) or 90,000(type Hex50) nanowells. SIEVEWELL™ is designed to trap cells at a high single cell rate. Fluidic system or instrument is not required. SIEVEWELL™ is a useful tool for single cell culture, staining, imaging and assay.