About

About SiriusXT Ltd SiriusXT has developed the only commercially-available laboratory instrument that is capable of non-destructively imaging the whole internal structure of intact cells or tissue slabs, with high natural contrast (label-free) and with nanometer-resolution. The microscope, called a Soft X-ray Microscope, uses an imaging modality that has been in use for over 30 years but which has only been available at six global, football stadium-sized, research facilities, called synchrotrons. SiriusXT has effectively miniaturized the synchrotron into a chamber measuring less than 3 feet in diameter, enabling the development of a table-top microscope. This means that the benefits of soft X-ray microscopy are now accessible 24/7, without having to wait for up to 12 months to get access to the synchrotron microscopes. Despite the very restricted access to the synchrotron-based microscopes many hundreds of peer-reviewed papers have been published by scientists working in disease research and therapeutic discovery where the images produced by the microscopes have helped in making significant advances in scientific state of the art. In biological research, Soft X-ray Microscopy can be used as a stand-alone cell and tissue structural imaging technique, where it can image sample thicknesses that are close to 50 times greater than can be imaged with electron microscopy. It can also be used in correlative imaging workflows, along with light and electron microscopy, to greatly increase (by a factor of over 20 times) the sample imaging throughput. Thirdly, it has been demonstrated that Soft X-ray Microscopy provides an effective means for tracking and validating the delivery of nanoparticle, carrying a cargo of therapeutics, vaccines or adjuvants, to targeted end points in cells. SiriusXT has commissioned its first commercial product, the SXT-100, in 2024 at a research university in Europe. It is now focused on introducing the SXT-100 to target customers in the US.