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About Preclina Inc About Preclina Inc. Autoimmune Specialists’ Research Service CRO: Preclina is a non-clinical CRO specialized in autoimune and inflammatory disorders, providing the utmost quality services for novel drug development at the lightning speed, highest quality, and reasonable cost. In the global market of immune disease therapeutics, which shows explosive growth, Preclina Inc is a leading company that supports bio and pharmaceutical companies to secure new drug development competitiveness by providing the highest quality evaluation results at the fastest speed for the optimization processes of candidate compounds. Our scientific expertise in autoimmune and inflammatory diseases has been accumulated over 20 years. Scientists in Preclina provide well-established service repertoire mostly based on therapeutic efficacy evaluation, and effectively designed support for drug development processes. We strive to satisfy our clients by providing innovative integrated modular platform of investigation that permits robust results with lightning speed. [Our preclinical services] ● In vivo efficacy pharmacology using disease models recapitulating autoimmune and inflammatory disorders ● Cell-based assays using patient-derived cells isolated from immune diseases ● Modular platform services for consistent and fastest track results (Modules: PreCIATa, PreBILFi, PreNASHa, PrePsora, and PreEXA) ● Premium Platform services integrating modular platform and patient-derived cellular assays which encompasses from lead selection to candidate development, thus dramatically reducing late failure rate of drug discovery Immune Specialists’ Research Service CRO: [ Booth # 4158] Preclina is a non-clinical CRO with a fully-integrated drug discovery platform specializing in Immunology. We offer a portfolio of models for efficacy pharmacology studies in autoimmunity, immuno-oncology, and transplantation immunology. Our platforms include humanized mouse models recapitulating autoimmune diseases and humanized tumor xenografts, enabling preclinical evaluation of biologics, cell therapies, and novel immunotherapies. With over 20 years of expertise in immunology, immunotoxicology, and bioanalysis, Preclina delivers integrated, customizable solutions with a focus on scientific rigor, speed, and cost-efficiency. Our advanced approaches help accelerate drug discovery and reduce development risk. We serve as a "Bridging Specialist" connecting non-clinical and clinical stages, supporting biotech and pharma partners in optimizing pipelines and making faster, smarter decisions in immunology drug development. Meet us at Booth # 4158. Our Preclinical Services: ● Comprehensive in vivo efficacy pharmacology services utilizing well-established autoimmune and inflammatory disease models, augmented by pioneering, technically advanced humanized autoimmune disease model platforms ● Humanized mouse models for immunotherapeutic development and pathogenesis research in oncology and transplantation immunology fields ● Cell-based assays using patient-derived cells isolated from immune diseases ● Modular platform services for consistent and the fastest results [PreVIVO™ Platform] Modules: PreCIATa, PreBILFi, PreNASHa, PrePsora, and PreEXA ● Premium Platform services integrating modular platform and patient-derived cellular assays which encompasses from lead selection to candidate development, thus dramatically reducing late failure rate of drug discovery Autoimmune Specialists’ Research Service CRO: Preclina is a non-clinical CRO specialized in autoimune and inflammatory disorders, providing the utmost quality services for novel drug development at the lightning speed, highest quality, and reasonable cost. In the global market of immune disease therapeutics, which shows explosive growth, Preclina Inc is a leading company that supports bio and pharmaceutical companies to secure new drug development competitiveness by providing the highest quality evaluation results at the fastest speed for the optimization processes of candidate compounds. Our scientific expertise in autoimmune and inflammatory diseases has been accumulated over 20 years. Scientists in Preclina provide well-established service repertoire mostly based on therapeutic efficacy evaluation, and effectively designed support for drug development processes. We strive to satisfy our clients by providing innovative integrated modular platform of investigation that permits robust results with lightning speed. [Our preclinical services] ● In vivo efficacy pharmacology using disease models recapitulating autoimmune and inflammatory disorders ● Cell-based assays using patient-derived cells isolated from immune diseases ● Modular platform services for consistent and fastest track results (Modules: PreCIATa, PreBILFi, PreNASHa, PrePsora, and PreEXA) ● Premium Platform services integrating modular platform and patient-derived cellular assays which encompasses from lead selection to candidate development, thus dramatically reducing late failure rate of drug discovery Preclina is a global leading non-clinical CRO that supports bio and pharmaceutical companies to secure new drug development competitiveness by providing the highest quality evaluation results at the fastest speed for the optimization processes of candidate compounds. Our scientific expertise in autoimmune and inflammatory diseases has been accumulated over 20 years. Scientists in Preclina provide well-established service repertoire mostly based on therapeutic efficacy evaluation, and effectively designed support for drug development processes. We're strengthening our leadership in immunological research by broadening our portfolio with sophisticated humanized mouse models, specifically optimized for oncology drug development. We strive to satisfy our clients by providing innovative integrated modular platform of investigation that permits robust results with lightning speed. Our preclinical services: ● In vivo efficacy pharmacology using disease models recapitulating autoimmune and inflammatory disorders ● Humanized mouse models for immunotherapeutic development and pathogenesis research in oncology and transplantation immunology fields ● Cell-based assays using patient-derived cells isolated from immune diseases ● Modular platform services for consistent and fastest track results Modules: PreCIATa, PreBILFi, PreNASHa, PrePsora, and PreEXA ● Premium Platform services integrating modular platform and patient-derived cellular assays which encompasses from lead selection to candidate development, thus dramatically reducing late failure rate of drug discovery Immune Specialists’ Research Service CRO: [ Booth #3816] Predict Your Clinical Success with "World’s First" Humanized Models Preclina is a "Bridging Specialist" that eliminates the uncertainty of the translational gap. We provide the high-fidelity data needed to turn early-stage assets into clinical success stories. 1. Proven Excellence in Immunology - Expertise: Over 20 years specializing in immunology, immunotoxicology, and bioanalysis. - Track Record: Contributed to $600M+ global license-out deals. - Reliability: Supported multiple assets achieving final FDA approval. 2. The PreHu™ Advantage: Unrivaled Predictive Power Gain an exclusive competitive edge with our quartet of World’s First & Pioneering commercialized humanized disease models: - World’s First Lineup: Our peer-reviewed models for Psoriasis, Atopic Dermatitis, BILF, and DSS-induced Colitis are the first of their kind commercialized globally. - Peer-Reviewed Authority: All four models are published in leading journals, ensuring high reproducibility and scientific rigor. - Translational Relevance: These platforms recapitulate the human immune system in a patient-like environment to accurately validate biologics and cell therapies. 3. Operational Speed & Strategy PreVIVO™ Platform: Access modular services (PrePsora, PreBILFi, PreNASHa, etc.) for the fastest, most consistent data. - Risk Reduction: Integrated services encompass lead selection to candidate development, dramatically reducing late-stage failure rates. - Strategic Grant: The PreTrial™ Program offers exclusive grant support to qualified companies to bridge the "PoC Hurdle" and boost asset valuation. Consult with our Global Business Development team to de-risk your pipeline today [ Humanized Mouse Model Platform (PreHu™) ] 1. Humanized CDX/PDX (Patient-Derived Xenograft)-Based Efficacy Services : This platform implants tumor cells/tissues into humanized mice for bio-pharmaceutical efficacy evaluations in a patient-like environment, crucial for immuno-oncology and cell therapy assessments. - Humanized CDX/PDX Model - Humanized PBMC/HSc Model - GvHD Model 2. Humanized Autoimmune Disease / Fibrosis Mouse Model : We have pioneered the world's first service platform with four or more humanized autoimmune disease models, providing essential preclinical services for the development of biopharmaceuticals, such as antibody drugs and cell therapies. - Humanized Ulcerative Colitis (UC) Model - Humanized Pulmonary Fibrosis (IPF) Model - Humanized Psoriasis Model - Humanized Atopic Dermatitis Model [Efficacy Evaluation Pharmacology Services (PreVIVO™) ] 1. Arthritis Research Service: Preclina’s service not only includes all essential models for evaluating the efficacy in the development of therapeutic agents for rheumatoid arthritis but also provides the key model for osteoarthritis - CIA Model / CAIA Model / ACLT Model 2. Fibrosis Research Service: With extensive expertise in immunology and fibrosis research, we have the flexibility to lead drug efficacy assessment projects with in-depth insights, maximizing the potential for success in new drug development. - BILF Model / BISF Model / MASH Model 3. Atopic Dermatitis & Psoriasis Research Service: Preclina provides specialized inflammatory skin disease models to support preclinical and mechanistic research in dermatology. These models include psoriasis, atopic dermatitis, and hypersensitivity disorders, enabling precise evaluation through mRNA analysis, protein assays, histopathology, and cellular assessments. With internationally standardized read-outs and customized research services, our models enhance the success rate of new drug development. - Imiquimod-Induced Psoriasis / IL-23-Induced Psoriasis Models - Oxazolone-Induced AD / House Dust Mite-Induced AD Models 4. Inflammatory Bowel Disease Research Service : Preclina provides specialized models for inflammatory bowel disease (IBD) research. These models include the ulcerative colitis model (Dextran Sodium Sulfate, DSS-induced colitis) and the Crohn’s disease model (Dinitrobenzene Sulfonic Acid, DNBS-induced colitis). These models accurately replicate disease onset and progression, enabling comprehensive disease activity index (DAI) assessments, histopathologic evaluations, biomarker analyses, and toxicity assessments. - DSS-Induced Colitis / DNBS-Induced Colitis Models 5. Lupus Research Service: Preclina provides key animal models for lupus and Sjogren syndrome research. For lupus, it supports the development of new drugs targeting B lymphocytes, cell surface molecules, signaling pathway proteins, and regulatory cytokines. It also offers a mouse model for Sjogren syndrome. - MRL/lpr Lupus Model / NZBW F1 Lupus Model 6. Neuroscience Research Service: Preclina provides a specialized EAE (Experimental Autoimmune Encephalomyelitis) animal model to support preclinical research and mechanistic studies on multiple sclerosis (MS). In particular, the MOG-induced EAE mouse model serves as a standard model that closely resembles the inflammatory pathogenesis of MS driven by autoimmune mechanisms, making it widely utilized for evaluating disease progression and treatment responses. - MOG EAE Model / PLP EAE Model [Non-GLP Toxicology service & ADME-PK ] Customized PK/ADME-Tox evaluation services for dramatically enhancing the potential for successful drug development.